Azenta. has been granted a patent for a system and method that regulates the freezing of specimen samples. The invention features a thermal insulating device with multiple chambers and a thermal ballast, allowing controlled and uniform removal of thermal energy to enhance freezing efficiency. GlobalData’s report on Azenta gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Azenta, Semiconductor fabrication robots was a key innovation area identified from patents. Azenta's grant share as of July 2024 was 59%. Grant share is based on the ratio of number of grants to total number of patents.

Thermal energy removal system for specimen sample freezing

Source: United States Patent and Trademark Office (USPTO). Credit: Azenta Inc

The granted patent US12070198B2 outlines a method and apparatus designed to regulate the freezing process of specimen samples, particularly live cell suspensions, to enhance cell survival during cryogenic storage. The method involves acclimating a specimen freezing rate regulator device to a specific temperature, which includes a container made from insulating materials and features multiple specimen containment chambers. Each chamber is geometrically positioned to ensure uniform temperature reduction. The process entails inserting an acclimated specimen sample into one of these chambers, along with a thermal ballast, and sealing the device before placing it in a colder environment. Notably, the thermal ballast modifies the temperature reduction profile, allowing the live cell suspension to take at least 30 minutes longer to reach a critical temperature compared to samples without the ballast.

The apparatus described in the patent consists of a container with a base and upper portion made from different insulating materials, designed to accommodate specimen vials and a central receiving well for the thermal ballast. The configuration of vertical cavities and the thermal ballast is intended to create a controlled temperature reduction profile of approximately -1°C per minute. The design ensures that each vertical cavity provides an identical temperature reduction profile for the samples, thereby promoting enhanced survival rates of live cell suspensions during the freezing process. The thermal ballast can be made from various materials and is designed to fit within the central receiving well, contributing to the overall effectiveness of the apparatus in cryogenic applications.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies