Ionis Pharmaceuticals. has been granted a patent for methods and compounds aimed at inhibiting IRF4 expression, potentially useful in treating cancers associated with IRF4. The patent includes a claim for a modified oligonucleotide composed of 15 to 30 linked nucleosides with a specific nucleobase sequence. GlobalData’s report on Ionis Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Ionis Pharmaceuticals, Nucleic acid active pharmaceutical ingredient was a key innovation area identified from patents. Ionis Pharmaceuticals's grant share as of July 2024 was 40%. Grant share is based on the ratio of number of grants to total number of patents.
The granted patent US12042510B2 outlines a novel compound consisting of a modified oligonucleotide that is 15 to 30 nucleosides in length. This oligonucleotide features a nucleobase sequence that includes at least 15 contiguous nucleobases from a specified sequence (SEQ ID NO: 2021). The claims detail various modifications that can be incorporated into the oligonucleotide, such as altered internucleoside linkages, sugars, and nucleobases. Notably, the modified internucleoside linkage may be a phosphorothioate, and the sugars can include bicyclic variants or 2'-O-methoxyethyl. The structure of the oligonucleotide can also include a gap segment of linked deoxyribonucleotides flanked by wing segments of linked nucleosides, with specific configurations and modifications outlined in the claims.
Additionally, the patent describes a composition that includes the modified oligonucleotide and a pharmaceutically acceptable carrier, as well as a method for treating or ameliorating various cancers, including multiple myeloma and other blood cancers. The administration of this composition is specified to be parenteral. The claims emphasize the potential therapeutic applications of the compound, particularly in the context of cancer treatment, highlighting its relevance in the development of targeted therapies for malignancies associated with B and T cells.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
