The Henry Ford Health System has been granted a patent for methods to prevent and treat cardiovascular diseases in patients with cerebrovascular injuries. The patent involves administering agents containing microRNA-126. GlobalData’s report on Henry Ford Health System gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Henry Ford Health System, was a key innovation area identified from patents. Henry Ford Health System's grant share as of May 2024 was 36%. Grant share is based on the ratio of number of grants to total number of patents.
Treatment of cardiovascular disorders with microrna-126 in diabetic stroke patients
A recently granted patent (Publication Number: US11957705B2) discloses a method for treating cardiovascular disorders or diseases in subjects with Type 2 Diabetes Mellitus who have suffered a stroke. The method involves administering exosomes containing miR-126, with the exosomes derived from CD133+ cells, specifically CD133+/KDR+ cells isolated from human umbilical cord blood cells. The concentration of miR-126 in these exosomes is highlighted as being higher than that found in exosomes from endothelial cells or human umbilical cord blood cells.
Furthermore, the patent claims that the exosomes may also contain miR-29b in addition to miR-126, with the concentration of miR-29b in these exosomes being greater than that in exosomes derived from endothelial cells or human umbilical cord blood cells. The therapeutic amount of exosomes administered is specified to be at least 3×1010, and the method is applicable to treating ischemic or hemorrhagic strokes, as well as heart failure and cardiomyopathy, particularly systolic heart failure with a left ventricle ejection fraction of less than 40%. The patent also mentions the derivation of exosomes from endothelial cells, specifically brain endothelial cells, for this treatment method.
To know more about GlobalData’s detailed insights on Henry Ford Health System, buy the report here.
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