Cue Biopharma‘s patent involves T-cell modulatory multimeric polypeptides (T-Cell-MMPs) that can deliver immunomodulatory peptides to T-cells in a specific manner, modulating immune responses. The polypeptides consist of specific components and chemical conjugation sites for attaching epitope peptides. GlobalData’s report on Cue Biopharma gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Cue Biopharma, CAR-T cell based therapies was a key innovation area identified from patents. Cue Biopharma's grant share as of May 2024 was 6%. Grant share is based on the ratio of number of grants to total number of patents.
T-cell modulatory polypeptides for immune response modulation
A recently granted patent (Publication Number: US12006348B2) discloses a T-cell modulatory multimeric polypeptide (T-Cell-MMP) designed to enhance immune responses. The T-Cell-MMP comprises a first polypeptide with a beta-2-microglobulin (ß2M) polypeptide and a second polypeptide containing a class I MHC heavy chain polypeptide with a binding pocket. Additionally, the T-Cell-MMP includes chemical conjugation sites for attaching epitope peptides and immunomodulatory polypeptides (MODs) at specific locations within the polypeptide structure.
Furthermore, the patent details the inclusion of variant MOD polypeptides in the T-Cell-MMP, with reduced affinity to their Co-MOD compared to wild-type MODs. These variant MODs aim to optimize the binding affinity of the T-Cell-MMP-epitope conjugate for enhanced immune response. The chemical conjugation sites within the T-Cell-MMP can be engineered amino acid sites, such as cysteine, strategically positioned for efficient conjugation. The T-Cell-MMP design ensures compatibility with various wild-type and variant MOD polypeptides, including IL-2, PD-L1, CD80, and others, to modulate T-cell responses effectively.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
