AbCellera Biologics has been granted a patent for a transgenic mouse with a unique long DH (LDH) expression cassette, allowing for the production of an immunoglobulin library with extended HCDR3 regions. The mouse genome features a combination of human and mouse gene segments to enhance antibody diversity. GlobalData’s report on AbCellera Biologics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on AbCellera Biologics, Molecular diagnosis biomarkers was a key innovation area identified from patents. AbCellera Biologics's grant share as of May 2024 was 22%. Grant share is based on the ratio of number of grants to total number of patents.
Transgenic mouse with long hcdr3 immunoglobulin library production
A recently granted patent (Publication Number: US11946063B2) discloses a transgenic mouse with a unique genetic makeup aimed at enhancing the expression of immunoglobulin heavy chain variable regions. The mouse's genome includes a combination of human variable region coding sequences and mouse non-coding sequences, along with a long DH (LDH) expression cassette that replaces all endogenous DH segments. This expression cassette contains 5-60 different human DH gene segments, with at least two directly fused segments encoding a heavy chain CDR3 (HCDR3) amino acid sequence of at least 10 amino acids. Additionally, one of the fused DH gene segments is mutated to remove stop codons, while the other is flanked by a mouse intergenic region, enabling the expression of a long HCDR3 amino acid sequence of at least 20 amino acids.
Furthermore, the patent details variations of the transgenic mouse, such as different lengths of the HCDR3 amino acid sequence (ranging from 20-61 amino acids), connections between fused DH gene segments via a mouse intergenic region, and the inclusion of additional bovine or human DH gene segments with specific characteristics like a 12 base pair recombination signal sequence (RSS) spacer or the deletion of stop codons. These modifications aim to optimize the expression of the long HCDR3 amino acid sequence in the transgenic mouse, potentially leading to advancements in immunoglobulin research and therapeutic development.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
