Singular Genomics Systems has been granted a patent for compositions and methods to detect RNA molecules in cells or tissues. The method involves hybridizing polynucleotide probes, generating circular oligonucleotides, amplifying the target sequence, and sequencing to detect the RNA molecule. GlobalData’s report on Singular Genomics Systems gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Singular Genomics Systems, DNA polymerase compositions was a key innovation area identified from patents. Singular Genomics Systems's grant share as of May 2024 was 10%. Grant share is based on the ratio of number of grants to total number of patents.
Method of detecting rna molecules in cells or tissues
A recently granted patent (Publication Number: US12006534B2) discloses a method for detecting RNA molecules in cells or tissues. The method involves contacting a cell or tissue with a polynucleotide probe that hybridizes to specific target sequences of the RNA molecule. By extending the polynucleotide probe along the target sequence, a complement of the target sequence is generated and ligated to the probe, forming a circular oligonucleotide. This circular oligonucleotide is then amplified using an amplification primer and polymerase, followed by sequencing the target sequence to detect the RNA molecule. The method allows for the detection of RNA molecules with high specificity and sensitivity.
Furthermore, the patent also describes a method for incorporating modified nucleotides into nucleic acid molecules in cells or tissues. By hybridizing a polynucleotide probe to specific target sequences of an RNA molecule and generating a circular oligonucleotide, modified nucleotides can be incorporated into the primer used for amplification. These modified nucleotides, which may contain a blocking group or detectable label, can be used to identify complementary nucleotides of the extension product. The method provides a novel approach for studying nucleic acid molecules within cells or tissues, offering potential applications in research and diagnostics.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
