Enzo Biochem has patented an antibody composition and method for assaying 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol, or 27-hydroxycholesterol. The method involves combining samples with specific antibodies and detecting binding. This innovation could advance research and diagnostics in related fields. GlobalData’s report on Enzo Biochem gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Enzo Biochem, Cancer treatment biomarkers was a key innovation area identified from patents. Enzo Biochem's grant share as of May 2024 was 50%. Grant share is based on the ratio of number of grants to total number of patents.
Method of assaying for 24(s)-hydroxycholesterol in samples
A recently granted patent (Publication Number: US11971419B2) discloses a method for assaying 24(S)-hydroxycholesterol in fluid or tissue samples from mammals. The method involves combining the sample with antibodies specifically binding to 24(S)-hydroxycholesterol, generated by immunizing a rabbit with a 24(S)-hydroxycholesterol immunogen. The antibodies are then collected and used to detect the presence of 24(S)-hydroxycholesterol in the sample. The carrier protein used in the immunization process can be keyhole limpet hemocyanin, bovine serum albumin, or ovalbumin. The method can be applied to samples from various sources, including cerebrospinal fluid, blood, brain tissue, or from individuals with cognitive impairment, Huntington's disease, Alzheimer's disease, or multiple sclerosis.
Furthermore, the patent describes a detailed method for assaying 24(S)-hydroxycholesterol using anti-24(S)-hydroxycholesterol polyclonal antibodies obtained through rabbit immunization. The method involves several steps, including noncovalently binding second antibodies to a solid phase, adding the anti-24(S)-hydroxycholesterol polyclonal antibodies, the sample, and biotinylated 24(S)-hydroxycholesterol to the solid phase, and measuring the absorbance of light at a specified wavelength to determine the amount of 24(S)-hydroxycholesterol present in the sample. The biotinylated 24(S)-hydroxycholesterol used in the assay is a biotin derivative of 3-O-succinoyl-24(S)-hydroxycholesterol N-hydroxysuccinimide ester. This method provides a reliable and efficient way to assay for 24(S)-hydroxycholesterol, which can be valuable in various research and diagnostic applications.
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