Hisamitsu Pharmaceutical has patented a method to quantitatively determine amphetacarbamate in drug-containing polymer matrices with amphetamine. The process involves separating components, converting amphetacarbamate to carbonate, and quantifying the original amount of amphetacarbamate. GlobalData’s report on Hisamitsu Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Hisamitsu Pharmaceutical, Microneedles for transdermal drug delivery was a key innovation area identified from patents. Hisamitsu Pharmaceutical's grant share as of May 2024 was 52%. Grant share is based on the ratio of number of grants to total number of patents.
Quantitative determination of amphetacarbamate in drug-containing polymer matrix
A recently granted patent (Publication Number: US11976026B2) discloses a method for quantitatively determining the amount of amphetacarbamate in a drug-containing polymer matrix that includes amphetamine and polymer components. The method involves processing the matrix with an organic solvent to separate the components, converting any amphetacarbamate present into carbonates using basic hydroxide ions, quantifying the carbonate content, and determining the original amount of amphetacarbamate based on the stoichiometric relationship between amphetacarbamate and carbonate. The method ensures accurate assessment of drug-containing polymer matrices, particularly in amphetamine transdermal delivery systems.
The patent also includes variations in the method, such as using specific basic hydroxide ions like potassium hydroxide, sodium hydroxide, or lithium hydroxide, conducting the process under an inert atmosphere, and employing specific solvents like methanol and water to isolate the components effectively. Additionally, the method involves ion chromatography with eluents containing basic hydroxide ions and the use of conductivity detectors for quantification. The patent aims to provide a reliable and precise technique for analyzing amphetacarbamate levels in polymer matrices, crucial for ensuring the quality and efficacy of drug delivery systems containing amphetamine.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
