Tipifarnib is under clinical development by Kura Oncology and currently in Phase II for Head And Neck Squamous Cell Carcinoma (HNSC). According to GlobalData, Phase II drugs for Head And Neck Squamous Cell Carcinoma (HNSC) have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Tipifarnib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Tipifarnib overview
Tipifarnib (Zarnestra) is under development for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL), clear cell renal cell carcinoma, recurrent head and neck cancer squamous cell carcinoma. The drug candidate is administered orally. It is a nonpeptidomimetic quinolinone. Tipifarnib is an inhibitor of farnesylation, a key cell signaling process implicated in cancer initiation and development.
It was also under development for the treatment of solid tumor, relapsed or refractory multiple myeloma, acute myeloid leukemia, advanced pancreatic cancer, higher risk myelodysplastic syndrome, breast cancer, glioblastoma multiforme, relapsed /refractory lymphomas including diffuse large b-cell lymphoma, mantle cell lymphoma, sezary syndrome , Hodgkin lymphoma, mycosis fungoides, extranodal marginal zone B-cell lymphoma (mucosa-associated lymphoid tissue or malt-lymphoma),nodal marginal zone B-cell lymphoma, splenic marginal zone b-cell lymphoma,refractory anemia with excess blasts in transformation and anaplastic large cell lymphoma, recurrent head and neck cancer squamous cell carcinoma including oral cavity, pharynx, larynx, sinonasal, nasopharyngeal, or unknown primary) and Hepatitis Delta virus (HDV) infections, non-small cell lung cancer, salivary gland cancer, angioimmunoblastic T-cell lymphoma, thyroid/solid tumors with HRAS mutations, follicular T-cell lymphoma (FTCL), extranodal natural killer T-cell lymphoma, lower risk myelodysplastic syndrome, undifferentiated myeloproliferative disorders, chronic myelocytic leukemia, chronic myelomonocytic leukemia (CMML) and HRAS mutant urothelial cancer.
Kura Oncology overview
Kura Oncology is a biopharmaceutical company that primarily focuses on the discovery and development of precision medicines for cancer treatment. Its main activities include the design of novel therapies that selectively target cancer cells, aiming to increase clinical benefits and address areas with high unmet needs. The company’s major products are its pipeline of precision medicines, including Ziftomenib, Tipifarnib, and KO-2806. Kura Oncology’s products are primarily used in the healthcare industry, specifically in the treatment of blood cancers and solid tumors. The company’s target market appears to be patients with cancer, particularly those with blood cancers and solid tumors. Kura Oncology is headquartered in San Diego, California, the US.
For a complete picture of Tipifarnib’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
