Bepranemab is a monoclonal antibody commercialized by UCB, with a leading Phase II program in Alzheimer’s Disease. According to Globaldata, it is involved in 5 clinical trials, of which 3 were completed, and 2 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Bepranemabs valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Bepranemab is expected to reach an annual total of $4 mn by 2039 in the US based off GlobalDatas Expiry Model. The drugs revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drugs phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Bepranemab Overview
Bepranemab is under development for the treatment of progressive supranuclear palsy, prodromal/mild cognitive impairment due to Alzheimer's disease (AD) or mild Alzheimer's disease and tauopathies. The therapeutic candidate is a recombinant humanized IgG4P administered intravenously as a solution for infusion. It acts by targeting tau protein.
UCB Overview
UCB is a biopharmaceutical company that is engaged in the discovery and development of novel medicines and solutions for the treatment of various severe diseases. It strives to develop products for the treatment of neurology and immunology related conditions. The company’s marketed products include Cimzia for ankylosing spondylitis, axial spondyloarthritis, Crohn’s disease, psoriatic arthritis, non-radiographic axial spondyloarthritis and rheumatoid arthritis; Neupro for Parkinson’s disease and restless legs syndrome; Evenity for osteoporosis, and Vimpat, Keppra and Briviact for epilepsy. The company operates through subsidiaries in the US, Japan, Germany, Italy, Spain, France, China, the UK, Ireland, Belgium, Brazil, Russia, India, Mexico, Turkey and other countries. UCB is headquartered in Anderlecht, Brussels-Capital Region, Belgium.
The company reported revenues of (Euro) EUR5,252 million for the fiscal year ended December 2023 (FY2023), a decrease of 4.8% over FY2022. In FY2023, the companys operating margin was 11.5%, compared to an operating margin of 10.6% in FY2022. In FY2023, the company recorded a net margin of 6.5%, compared to a net margin of 7.6% in FY2022.
For a complete picture of Bepranemabs valuation, buy the drugs risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
