Hemoglobinuria is an indication for drug development with over 40 pipeline drugs currently active. According to GlobalData, preregistered drugs for Hemoglobinuria have a 100% likelihood of approval (LoA) indication benchmark. GlobalData’s report assesses how phase transition success rate (PTSR) and likelihood of approval (LoA) scores for pipeline drugs in Hemoglobinuria compared to historical benchmarks. Buy the report here.
Smarter leaders trust GlobalData
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Hemoglobinuria overview
Hemoglobinuria is a condition characterized by the presence of free hemoglobin in the urine. Hemoglobin is the protein in red blood cells responsible for transporting oxygen throughout the body. When red blood cells break down, the released hemoglobin can be filtered by the kidneys and appear in the urine, giving it a red or brown color. Hemoglobinuria can result from various conditions, including hemolytic anemia, which includes conditions that cause breakdown of red blood cells, such as autoimmune hemolytic anemia, infections, certain medications, or inherited disorders like sickle cell disease or thalassemia; transfusion reactions, which are incompatibility or adverse reactions to blood transfusions, leading to the destruction of donor red blood cells; rhabdomyolysis, which refers to muscle injury or breakdown from trauma, strenuous exercise, or certain medications, and can release myoglobin (a similar protein to hemoglobin) into the bloodstream, causing hemoglobinuria. Severe cases of malaria can also result in hemolysis (rupture of red blood cells), leading to hemoglobinuria. The main visible symptom of hemoglobinuria is discolored urine—usually red or brown in color. Other associated symptoms may depend on the underlying cause and include fatigue, weakness, jaundice (yellowing of the skin or eyes), abdominal pain, or signs of anemia (pale skin, shortness of breath).
For a complete picture of PTSR and LoA scores for drugs in Hemoglobinuria, buy the report here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
