Cidara Therapeutics. has filed a patent for methods to synthesize conjugates for treating viral infections. The conjugates contain viral neuraminidase inhibitors linked to an Fc domain monomer. Claim 1 outlines the method for synthesizing these conjugates. GlobalData’s report on Cidara Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Cidara Therapeutics, Nanoparticle drug conjugates was a key innovation area identified from patents. Cidara Therapeutics's grant share as of January 2024 was 27%. Grant share is based on the ratio of number of grants to total number of patents.
The patent application (Publication Number: US20240024497A1) describes a method for synthesizing a conjugate of formula (M-I) or (D-I) involving anti-influenza moieties, small molecules like pimovidir, oseltamivir, zanamivir, and others. The method includes selecting specific formulas for A1 and A2, with R being halo, and m varying from 1 to 5. The process involves conducting steps at specific temperatures and durations, utilizing buffers like borate or carbonate with defined pH ranges. Purification steps such as dialysis in arginine buffer and buffer exchange are also detailed.
Furthermore, the method extends to the use of a Cu(I) source, combining compositions to form mixtures, and incorporating Ga and Gb groups with specific characteristics like carbonyl, amino, azido, or alkynyl groups. The resulting conjugate structures are outlined, with variations in n and E components, including Fc domain monomers or specific amino acid sequences. The method also covers scenarios where n is 1, and E is an albumin protein. Overall, the patent application provides a detailed and structured approach to synthesizing conjugates with anti-influenza properties, emphasizing specific conditions, compositions, and purification steps to achieve the desired outcomes efficiently.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
