CCAR-066 is under clinical development by Janssen Biotech and currently in Phase I for Marginal Zone B-cell Lymphoma. According to GlobalData, Phase I drugs for Marginal Zone B-cell Lymphoma have an 82% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how CCAR-066’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
CCAR-066 overview
CCAR-066 (CBM.CD20 CAR-T) is under development for the treatment of chemotherapy resistant or refractory CD20+ leukemia and lymphoma including b-cell non-Hodgkin lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone b-cell lymphoma, B-cell prolymphocytic leukemia (PLL) and diffuse large B-cell lymphoma. The therapy is administered through intravenous route as infusion. The therapy is composed of anti-CD20-CAR lentivirus vector-transduced autologous T cells that target CD20 cancer cells.
It was also under development for the treatment of refractory chronic lymphocytic leukemia (CLL).
Janssen Biotech overview
Janssen Biotech, a subsidiary of Johnson & Johnson, is a manufacturer and markets solutions for oncology, immunology, cardiovascular, and metabolic diseases that develop and commercializes therapeutic and diagnostic products. The company is headquartered in Montgomery, Pennsylvania, the US.
For a complete picture of CCAR-066’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
