ALG.APV-527 is under clinical development by Alligator Bioscience and currently in Phase II for Metastatic Breast Cancer. According to GlobalData, Phase II drugs for Metastatic Breast Cancer have a 32% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how ALG.APV-527’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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ALG.APV-527 overview
ALG.APV-527 is under development for the treatment of metastatic solid tumors such as colon carcinoma, melanoma, breast cancer, cervical cancer, non-small cell-lung cancer, prostate cancer, endometrial cancer, renal cancer, gastric cancer, colorectal cancer, malignant mesothelioma, malignant pleural mesothelioma, urothelial carcinoma, head and neck cancer, pancreatic cancer, ovarian cancer, throat cancer and gastroesophageal (GE) junction carcinomas. It is based on SLIMCAN concept. The drug candidate is a bi-specific antibody that acts by targeting 4-1BB (CD137), a member of tumor necrosis factor receptor superfamily (TNFRSF) and 5T4 protein. It is developed using ALLIGATOR-GOLD and FIND (Fragment Induced Diversity) technology. It is administered through intravenous route.
Alligator Bioscience overview
Alligator Bioscience develops antibody-based pharmaceuticals for cancer treatment. Its pipeline products include mitazalimab treats solid metastatic tumors and pancreatic cancer; ATOR-4066 targets solid metastatic tumors; ALG.APV-527 for solid metastatic tumors and ATOR-1017 targets solid metastatic tumors. Its Partner Programs include AC101/HLX22 for gastric cancer and bispecific program. It develops immunotherapeutic product candidates using proprietary technologies such as Alligator-Gold and fragment-induced diversity (FIND). Alligator Bioscience is headquartered in Lund, Sweden.
For a complete picture of ALG.APV-527’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
