Evofosfamide is under clinical development by Molecular Templates and currently in Phase I for Head And Neck Squamous Cell Carcinoma (HNSC). According to GlobalData, Phase I drugs for Head And Neck Squamous Cell Carcinoma (HNSC) have a 79% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Evofosfamide’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Evofosfamide overview
Evofosfamide (TH-302) is under development for the treatment of metastatic pancreatic neuroendocrine tumors (pNET), hepatocellular carcinoma, human papillomavirus (HPV) negative squamous cell carcinoma of head and neck, recurrent glioblastoma (GBM), intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma and gallbladder carcinoma. The drug candidate is administered through intravenous route.
It was also under development for the treatment of metastatic or locally advanced unresectable pancreatic ductal adenocarcinoma, metastatic soft tissue sarcoma, non-squamous non-small cell lung cancer, relapsed/refractory multiple myeloma, acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, myelodysplastic syndromes, myelofibrosis, chronic lymphocytic leukemia (CLL), gastrointestinal stromal tumors, renal cell carcinoma (RCC), neuroblastoma, castration resistant prostate cancer, metastatic melanoma, metastatic biliary tract carcinoma, esophageal cancer and adenocarcinoma of the gastroesophageal junction.
Molecular Templates overview
Molecular Templates, Inc. (Molecular Templates) is a biopharmaceutical company primarily focused on the development of novel therapies for oncology. The company’s proprietary biologic-engineered toxin body (ETB) drug platform is designed to target and destroy cells through unique mechanisms of action. MTI’s pipeline products include MT-6402, MT-8421, and MT-0169. MT-6402 is a third-generation ETB targeting PD-L1, with enhanced internalization and de-immunization. It utilizes antigen seeding technology to deliver a viral antigen. MT-8421 is being developed for targeting CTLA-4-expressing Tregs in the tumor microenvironment for cancer treatment. MT-0169 is being developed for the treatment of multiple myeloma. MTI is headquartered in Austin, Texas, the US.
For a complete picture of Evofosfamide’s drug-specific PTSR and LoA scores, buy the report here.
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