BioCina announced the expansion of its partnership with GPN Vaccines. Credit: BioCina /PR Newswire.

Contract development and manufacturing organisation (CDMO) BioCina has expanded its collaboration with GPN Vaccines to develop a vaccine against Streptococcus pneumoniae.

Known as Gamma-PN, the engineered whole-cell vaccine acts on the bacterium that causes infections such as pneumonia, bacteraemia and meningitis.

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GPN’s vaccine technology is an engineered Streptococcus pneumoniae strain without capsular polysaccharide.

BioCina will produce current good manufacturing practice batches for the vaccine programme on a large-scale basis at its facility in Adelaide, Australia.

The Adelaide site focuses on the development and production of recombinant proteins in microbial systems such as E coli.

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GPN Vaccines chairman and CEO professor Tim Hirst stated: “We are delighted to be progressing with the next stage of cGMP manufacture of our innovative whole-cell pneumococcal vaccine, Gamma-PN, with BioCina as the CDMO of choice. 

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“They successfully optimised the manufacture of Phase I material, and we now look forward to working with them to deliver a scaled-up process for the manufacture of Phase II material suitable for clinical evaluation worldwide.”

There are more than 100 serotypes of S pneumoniae and the currently marketed vaccine offers protection from only 20 of them.

Gamma-PN will be developed to offer protection to adults and children against all strains of S pneumoniae, irrespective of serotype status.

BioCina CEO Mark Womack stated: “We are extremely proud that GPN Vaccines has asked us to further scale up the production of Gamma-PN, which has the potential to protect so many lives against a broad range of serotypes not covered by any current vaccines.”