(IO-102 + IO-103) is under clinical development by IO Biotech and currently in Phase II for Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer). According to GlobalData, Phase II drugs for Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer) have a 72% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how (IO-102 + IO-103)’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
(IO-102 + IO-103) overview
PD-L1/IDO (IO102/IO103) peptide vaccine is under development for the treatment of melanoma, metastatic melanoma, head and neck cancer and non muscle invasive bladder cancer (NMIBC), metastatic non-small cell lung cancer (NSCLC), squamous cell carcinoma of head or neck (SCCHN), metastatic urothelial bladder cancer (mUBC), ureter cancer, kidney cancer (renal cell cancer), bladder cancer, urethral cancer, lung adenocarcinoma, metastatic transitional cell carcinoma (urothelial cell carcinoma), oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer and laryngeal cancer and metastatic solid tumors. It comprises of programmed cell death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase (IDO) peptides. It acts by targeting PD-L1 and IDO. It is developed based on T-win technology. It is administered through subcutaneous route.
It was under development for head and neck cancer.
IO Biotech overview
IO Biotech is a clinical-stage biopharmaceutical company that develops disruptive immune-modulating anti-cancer drugs. The company is investigating IO102-IO103, novel immune-modulating vaccines for the indications of melanoma and solid tumors. It also offers IO112 and IO170 for solid tumors. IO Biotech also utilizes T-win technology platform to discover, design and validate new immune-modulating vaccine candidates. IO Biotech is headquartered in Copenhagen, Denmark.
For a complete picture of (IO-102 + IO-103)’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
