ABL-001 is under clinical development by Compass Therapeutics and currently in Phase II for Metastatic Colorectal Cancer. According to GlobalData, Phase II drugs for Metastatic Colorectal Cancer have a 34% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how ABL-001’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
ABL-001 overview
ABL-001 (TR-009) is under development for the treatment of solid tumors such as gastric cancer, colon cancer, advanced or metastatic colorectal cancer (CRC), non small lung cancer, pancreatic cancer, gastrointestinal stromal tumor and ovarian cancer, colorectal cancer, gallbladder cancer, ampullary carcinoma, metastatic biliary tract cancer and endometrial cancer. It is administered through intravenous infusion. The drug candidate is a bi-specific monoclonal antibody. It acts by targeting vascular endothelial growth factor (VEGFA) and delta like protein 4 (DLL4). The drug candidate is developed based on bi-specific antibody technology.
Compass Therapeutics overview
Compass Therapeutics a biotechnology company. The company’s product pipeline includes CTX-471, CTX-009, CTX-8371 and others. It develops transformational therapies for cancer, inflammation and autoimmune diseases. The company is into the discovery of antibody-drug candidates with a focus on T cells, NK cells and macrophages. Compass Therapeutics develops both agonists and antagonists, which facilitate the development of monotherapies and combination therapies. It utilizes Sympleitope technology platform for epitope screening and selection; and StitchMabs, a novel multi specific antibody screening platform that combines monoclonal antibodies into various specific formats. Compass Therapeutics is headquartered in Boston, Massachusetts, the US.
For a complete picture of ABL-001’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
