INO-5401 is a dna vaccine commercialized by Inovio Pharmaceuticals, with a leading Phase II program in Glioblastoma Multiforme (GBM). According to Globaldata, it is involved in 3 clinical trials, of which 1 was completed, 1 is ongoing, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of INO-5401’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for INO-5401 is expected to reach an annual total of $23 mn by 2037 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
INO-5401 Overview
INO-5401 is under development for the treatment of newly diagnosed glioblastoma multiforme. The therapeutic candidate consist of three synthetic DNA plasmids encoding for three tumor associated antigens which includes human telomerase (hTERT), Wilms tumor gene-1 (WT1) and PSMA antigens. It is administered intramuscularly using the CELLECTRA delivery device. It is developed based on SynCon vaccine platform, ASPIRE technology. It was also under development for the treatment of advanced unresectable or metastatic urothelial carcinoma.
Inovio Pharmaceuticals Overview
Inovio Pharmaceuticals (Inovio) is a biotechnology company that focuses on developing DNA immunotherapies and vaccines for the treatment and prevention of various cancers and infectious diseases. The company develops products based on its core SynCon DNA plasmid technology and electroporation delivery technology. Its product pipeline includes VGX-3100 for the treatment of cervical HSIL, vulvar HSIL, anal HSIL; INO-5401 for glioblastoma; and INO-3107 for recurrent respiratory papillomatosis (RRP). The company is also engaged in development programs in partnership with several companies and government bodies to develop therapeutics for infectious diseases such as HIV, Ebola, Zika virus, Middle East respiratory syndrome (MERS), Lassa fever and COVID-19. Inovio is headquartered in Plymouth Meeting, Pennsylvania, the US.
For a complete picture of INO-5401’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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