PMV Pharmaceuticals has been granted a patent for compounds and methods that restore DNA binding affinity of p53 mutants, aiding in tumor suppression. The compounds can bind to mutant p53, activating downstream effectors to reduce cancer progression. GlobalData’s report on PMV Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on PMV Pharmaceuticals, Targeted cancer therapy was a key innovation area identified from patents. PMV Pharmaceuticals's grant share as of February 2024 was 17%. Grant share is based on the ratio of number of grants to total number of patents.
The granted patent (Publication Number: US11926632B2) discloses a compound of a specific formula, with variations in the substituents denoted by X1, R1, R6a, R6b, R6c, R6d, R6e, R7, NR3R4, R8, R9, R10, R14, and R15. The compound can have X1 as either CR7 or N, R1 as H, —C(O)NR8R9, —OR10, or CN, and different configurations for R6a, R6b, R6c, R6d, and R6e. Additionally, R7 can be H, and NR3R4 can have specific variations as well.
Furthermore, the compound can have specific configurations for R6b, such as —C(O)NR14R15, —NR14R15, or —NR14C(O)R15. The patent also specifies variations for NR3R4, R8, R9, R10, R14, and R15 within the compound. These detailed claims outline the specific structural features and substituents that can be present in the compound, providing a comprehensive understanding of the molecular composition and potential variations within the scope of the patent.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
