c-LEcta GmbH - Innovative Enzyme Technology

c-LEcta provides innovative enzyme technologies to the pharmaceutical and the biotech industry. By using enzymes and micro-organisms new bio-catalytic synthesis processes are developed to produce your small molecule drug. By combining powerful proprietary technologies in the field of enzyme discovery and enzyme engineering customized biocatalysts are developed and implemented in bio-catalytic transformations to synthesize the molecules of your interest.

Enzyme development and enzyme-based processes

From the start of the company in 2004 c-LEcta has rapidly developed towards a well-established and successful technology company focusing on the development of new enzymes and enzyme-based processes. The company cooperates with industry partners and provides its patent-protected technologies to create new business opportunities. c-LEcta engages a team of highly educated and experienced scientists with a long track-record of successful projects in the field of enzyme technologies.

Bio-catalytic transformations on defined starting molecules

c-LEcta is specialized in the provision of new bio-catalytic transformations to be implemented in synthesis routes for pharmaceutical molecules. Enzymes are a very powerful catalyst bringing along a very high enantioselectivity and stereo-selectivity combined with mild reaction conditions and high effectiveness. These are the reasons why enzyme-based transformations are rapidly being implemented in the production processes of pharmaceutical intermediates and APIs.

Innovate your synthesis processes and decrease their costs by making use of c-LEcta’s unique and proprietary bio-catalysis technology.

Biodiversity libraries

In order to identify new enzymatic activities in nature c-LEcta has expanded and implies a huge collection of biodiversity libraries. The company owns a large collection of isolated and qualified micro-organisms comprising more than 10,000 different organisms. Besides, large collections of metagenome libraries from different well-defined habitats have been produced and are available. This in combination provides a broad and unique access to biodiversity for the discovery of new enzymes for bio-catalytic transformations.

For the screening of the libraries a patent-protected technology called Cluster-Screening is used. It allows the identification of new enzyme activities in enzyme libraries with unrivalled effectiveness and speed.

Artificial enzyme development

Besides the discovery of new enzymes in natural sources c-LEcta also takes care of the development of artificial enzymes by enzyme engineering technologies. The company applies a patent-protected mutagenesis technology to create focussed variant libraries of enzymes. These libraries are screened with c-LEcta’s Cluster-Screening technology. This unique combination of technologies allows the provision of artificially made biocatalysts with completely new properties and activities.

c-LEcta’s biocatalysis approach

The combination of natural diversity screening and enzyme engineering technologies allows c-LEcta to rapidly develop and provide almost any desired enzyme activity for its partner’s needs. The reaction spectrum of bio-transformations provided by c-LEcta ranges from hydroxylations, epoxidations, transamination to esterifications and ketone reductions for instance. c-LEcta also takes care of process development and implementation as well as the scale of the biocatalyst production processes.